Eric Dane, best known for his roles as Dr. Mark Sloan on Grey's Anatomy and Cal Jacobs on Euphoria, has died at the age of 53, less than a year after revealing he had amyotrophic lateral sclerosis (ALS).
Dane shared his ALS diagnosis in April 2025 and spent his final months advocating for research and raising awareness about the disease. He joined the board of directors for Target ALS and helped campaigns exceed fundraising targets, while also appearing on-screen to highlight the struggles of living with ALS.
His family said in a statement: “With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS. He spent his final days surrounded by friends, his devoted wife, and his two daughters, Billie and Georgia, who were the center of his world. He will be deeply missed and lovingly remembered always.” Dane was married to actress and model Rebecca Gayheart.
Born in San Francisco in 1972, Dane made his television debut on The Wonder Years in 1993 and went on to star in series including Charmed and The Last Ship. His film credits include Marley & Me, Valentine’s Day, and Burlesque.
Tributes poured in from colleagues and fans alike. Patrick Dempsey, who played Dr. Derek Shepherd on Grey’s Anatomy, remembered Dane as “the funniest man” and praised his efforts to raise awareness for ALS. Co-stars Kim Raver and Kevin McKidd also paid tribute to his warmth, humour, and professionalism.
Creator of Euphoria, Sam Levinson, said: “Working with him was an honor. Being his friend was a gift.” Former Charmed co-star Alyssa Milano described Dane as a devoted father and partner, noting how he carried his family with him in everything he did.
Dane had recently been recognised by Time magazine as one of the 100 most influential people in health for his advocacy work. In interviews, he reflected on the personal impact of ALS, describing his determination to raise awareness and fund research to help others living with the disease.
Fans and colleagues remembered Dane not only for his iconic roles but also for his generosity, passion, and courage in the face of a devastating diagnosis.