The first case of Mpox has been reported in Sasolburg in the Free State.
The Provincial Health Department says the infected individual is clinically stable, isolating at home and receiving appropriate care.
Departmental spokesperson Mondli Mvambi says a small number of close contacts are being traced, with assessments and testing under way.
He says the risk to the general public remains low, with no evidence of widespread community transmission.
Mpox is an infectious disease caused by the monkeypox virus. It can spread through close physical contact with an infected person, including skin-to-skin and sexual contact, as well as through contaminated clothing or bedding.
Mvambi has urged residents to familiarise themselves with the symptoms, which may include flu-like symptoms and a rash affecting the face, hands, feet, genitals and other parts of the body.
He advises anyone who develops symptoms to seek medical attention and avoid close physical or sexual contact with others.
Residents are also urged to cover skin lesions, wash their hands regularly and avoid sharing clothing or bedding.
Close contacts who do not have symptoms should monitor their health for 21 days.